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ISBN 978-0-470-37668-3

The reasons are specific and addressable when identified early in the protocol

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72 CAR T-cell therapy directly targets tumor surface antigens via engineered CARs, completely bypassing the tumor cell-intrinsic MHC class I antigen presentation pathway, whereas CAR-NK cell therapy integrates CAR-directed cytotoxicity with the innate missing-self recognition of NK cells, enabling efficient elimination of tumor cells with downregulated or absent MHC class I expression and thereby directly addressing resistance mechanisms