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Obesity is a major contributor to degenerative spine disease, knee osteoarthritis, and chronic musculoskeletal pain

The FDA ended this practice in March 2025 after confirming that the shortage was resolved, citing safety concerns about unregulated compounded versions

Patients currently using AOM tirzepatide may need to switch to AOM semaglutide to maintain insurance coverage of the medication, while those wishing to remain on tirzepatide may face higher out-of-pocket costs or coverage denials

In the AIM-HIGH trial, 4 cases (0.2%) of rhabdomyolysis were reported in the niacin

Comparative effectiveness research could help identify optimal energy device selection and operating parameters for specific clinical situations