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Epigenetic silencing of antigen presentation machinery, including Polycomb-mediated repression and DNA hypermethylation at the HLA class I/NLRC5/interferon axis, further diminishes peptide display and limits T cell recognition (36)
In the mitochondrial pathway, H 2 O 2 increases calcium ion concentrations within the mitochondria [77], regulates Bcl-2 family protein expression and activity, leading to decreased mitochondrial membrane potential, cytochrome c release, and ultimately triggering apoptosis [78]
The peptide has attracted special attention in the field of sports scientists and athletic researchers studying recovery mechanisms
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