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Animal Toxicology Studies Animal toxicology studies tested doses from 0.0027 mg/lb to 9.1 mg/lb via intraperitoneal, intramuscular, intravenous, and oral routes for up to 6 weeks, finding: No acute toxic or lethal dose No gross or histologic toxicity in major organs No hepatotoxicity or nephrotoxicity Negative Ames test (no mutagenicity) Negative chromosomal aberration tests (no genotoxicity) No teratogenicity in rat pregnancy studies No local injection site irritation The LD1 (minimum lethal dose) could not be achieved despite aggressive testing

You can help prevent peripheral nerve disorders by: Managing health conditions that may cause nerve damage, especially diabetes Preventing falls and accidents Avoiding toxic substances Being careful to avoid repeated motions and body positions that press on your nerves Eating a balanced diet, exercising, limiting alcohol, and not smoking NIH: National Institute of Neurological Disorders and Stroke [Learn More in MedlinePlus] Code History FY 2026 - No Change, effective from 10/1/2025 through 9/30/2026 FY 2025 - No Change, effective from 10/1/2024 through 9/30/2025 FY 2024 - No Change, effective from 10/1/2023 through 9/30/2024 FY 2023 - No Change, effective from 10/1/2022 through 9/30/2023 FY 2022 - No Change, effective from 10/1/2021 through 9/30/2022 FY 2021 - No Change, effective from 10/1/2020 through 9/30/2021 FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020 FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019 FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018 FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017 FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016

100, Fort Myers, FL 33916 Call: 1-239-277-7070 Visit: www.gardnerorthopedics.com