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This approach leads to improved glycemic control and substantial weight loss, with clinical trials demonstrating HbA1c reductions of 1.9% to 2.4% and mean weight loss of approximately 15-21% in the SURMOUNT-1 trial, with up to 22.5% weight loss observed in some patients at the highest doses

Such results should be interpreted with caution

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The STEP trials evaluating semaglutide 2.4 mg for weight management reported gallbladder disorders in approximately 1.6-2.6% of participants receiving the medication versus 0.7-1.2% receiving placebo