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Sakadic, S

Current clinical studies on DOR primarily focus on genome sequencing and mutation identification, while the underlying disease mechanisms and signaling pathways remain underexplored

West AP Jr, Bjorkman PJ

The amplitude (A) of spontaneous and Ca 2+ -induced swelling of the organelle suspension in a Ca 2+ -free medium and in the conditions of pore-formation activation with the action of PTP inducer of swelling of calcium ions was calculated as the difference in optical density values from 1 to 15 min mPTP-associated mitochondrial swelling was tested by the specific mPTP inhibitor cyclosporin A (CsA), which was added to the incubation medium in a concentration of 10 5 mol/L 5 min before the induction of pore formation