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Moreover, transferrin-conjugated nanoparticles have shown potential in the delivery of antileukemic drugs: Transferrin-conjugated lipid nanoparticles delivering an antisense oligonucleotide targeting BCL2 mRNA induced caspase-dependent apoptosis in AML cell lines and suppressed tumor growth of human AML xenograft tumors in mice (187, 188)

To estimate transition probabilities for this study, we included all Australians with type 2 diabetes who do not identify as Aboriginal or Torres Strait Islander who were registered on the NDSS in four Australian states (80% of the NDSS) at any point between 1 July 2010 and 30 June 2019 (median age 68.9 [IQR 59.077.6]

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Dihexa remains in research stages with ongoing clinical evaluations to establish its long-term safety profile and standardized dosing protocols

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