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Presented for research literature review only Karalis DT et al
In addition, OCTN2 protein was detected in exosomes released from HEK293 cells [166], indicating that carnitine and its derivatives may be transported between cells through exosomes, a finding that provides new insights into the role of carnitine and its transporters in exosomes and their functions in intercellular communication and pathological processes
However, under conditions of imbalance, which can be caused by elevated levels of RAGE ligands, including either endogenous or dietary AGEs, this scenario may shift toward the development of chronic carbonyl/oxidative stress and related diseases
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