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The hallmark pathologies in AD are the accumulation of amyloid-beta (A) plaques and tau tangles in the brain, leading to neuronal loss and brain atrophy [3, 4]

Coskun T, Heise T, DeVries J et al (2022) Tirzepatide reduces appetite, energy intake and fat mass in people with type 2 diabetes

32,33 Childhood vaccination against varicella-zoster virus (Varivax or ProQuad) is over 90% effective at preventing chickenpox, and is recommended by the CDC for most children

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Note honestly that human-interest senolytic dosing is typically pulsed/intermittent (a few consecutive days per cycle), so this continuous once-daily-for-16-weeks schedule diverges from the typical senolytic paradigm