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Tirzepatide is the established option with FDA approval, extensive clinical trial data, and growing real-world evidence supporting its efficacy in both type 2 diabetes and obesity

85% of patients achieved more than 5% weight loss compared to 26% on placebo

44, 45, 46, 47 This is on account of the presence of low copy repeat sequences flanking the deleted region, 45 which may result in aberrant recombination of the segment during meiosis

Karagiannis T, Liakos A, Bekiari E et al (2015) Efficacy and safety of once-weekly glucagon-like peptide 1 receptor agonists for the management of type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials

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