One Reddit user mentioned that the sleep problems subsided after getting used to the medication, saying, At first, it didnt seem to make much of a difference as the dosage was so low, but over time with higher dosing I got less and less sleep (of the little I was getting.) Once the adjustment process was over, I went back to my baseline. Dry mouth Approximately 8.1% of participants in clinical studies for Contrave experience dry mouth
Resuming after you've recovered (when you can tolerate food and fluids again) allows your body to continue benefiting from the medication without unnecessary suffering
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Consulting with a healthcare professional can help determine the most appropriate dosage for your unique needs
Furthermore, in acquired models of 5FU resistance that show mitochondrial dysfunction, combination of ETC CI inhibition (by metformin and others) and 5FU treatment increased tumour control