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Ait-Belgnaoui A, Durand H, Cartier C, Chaumaz G, Eutamene H, Ferrier L et al (2012) Prevention of gut leakiness by a probiotic treatment leads to attenuated HPA response to an acute psychological stress in rats

89 Berberine has been shown to be effective in human studies for the treatment of diarrhea of various etiologies

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That overall rate was actually lower in the ipamorelin arm, though the study was not powered to detect safety differences

However, with an emphasis on safety and tolerability in humans, it did not aim to conclude with any significant new findings, but rather to support earlier ones