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This mechanism explains why chronic heavy drinkers develop accelerated liver damage despite increased ethanol clearance speed
dose coupling identifies an exposure relationship, not the molecular pathway
Lower doses provide sustained pathway support without aggressive intervention
The decrease in myocardial contractability and heart rate, as well as the reduction in blood pressure, produced by atenolol generally lead to a reduction in myocardial oxygen consumption which accounts for the effectiveness of the drug in chronic stable angina pectoris
