Contraindications Given the limited safety data, conservative contraindications would include pregnancy or plans to become pregnant, breastfeeding, age under 18, severe liver or kidney disease, and any condition requiring medications with unknown interaction potential
The member also noted that serious safety events like liver damage are not detectable through patient self-report, making post-market surveillance inadequate as a substitute for pre-market clinical trials
It also includes discussions of specific individual cases
By tightening muscles and removing excess tissue, circumferential reduction can improve the overall body contour and reduce sagging skin around the abdomen, lower back, arms, thighs, and sides
Early investigations demonstrated that amylin signaling plays an important role in appetite regulation, satiety pathways, gastric emptying, and energy balance