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Together, these findings necessitate further investigations to ascertain whether coordinated inhibition of NMDA receptors in GLP-1 receptor neurons modulates neuronal activity beyond canonical feeding regions, such as the mesolimbic dopaminergic reward pathway

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A review of GLP-1 agonist studies using the standard dose in high intracranial pressure reported: Patients should be counseled about the high likelihood of nausea and GI upset (diarrhea, vomiting, and constipation, delayed gastric emptying) especially in the first 48 weeks of therapy

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161 There is limited evidence available demonstrating who is likely to respond well to EPAP, but it is generally not recommended for patients with severe obstructive sleep apnea, reduced airway size or lung volume, high risk for airway collapse, nasal obstruction, blood gas abnormalities, or for use after stroke