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In muscle and adipose tissue, GLP-1RA increases insulin sensitivity, promotes glucose uptake and utilization, and reduces the release of free fatty acids (FFA) produced by fat breakdown
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2019;73(2):354363.e3
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The RRM2 gene is located on chromosome 2p25.1 and is composed of 14 exons that generate two alternatively spliced mRNAs encoding two distinct protein isoforms (isoform 1: 449 amino acids and isoform 2: 389 amino acids)
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