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One of the investigators described the average change in waist circumference on sema-bima (-22cm) as going from a 42 34 in mens waist sizes
The clinical development program was discontinued after reaching phase II trials
These findings raise concerns about potential microbiome disruption and inflammatory effects associated with long-term exposure, warranting further investigation in human studies
Blood pressure and lipid markers often begin improving during this window, independent of weight loss magnitude
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![Mechanism of action of GLP-1 [25]](https://www.researchgate.net/profile/Asfandyar-Sheikh/publication/256289222/figure/fig1/AS:614177232142337@1523442671231/Mechanism-of-action-of-GLP-1-25.png)
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