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Chronic kidney disease and cardiovascular risk: epidemiology, mechanisms, and prevention
There is something biologically there
The data presents a head-to-head comparison with industry-leading competitors.
However, once blood glucose reaches normal levels, continued administration of GLP-1 does not further stimulate insulin secretion, and blood glucose remains stable
This is reflected by the activity of protective antioxidant pathways such as mitochondrial uncoupling and the Nuclear factor E2-related factor 2 (NRF2), which are weakened or bypassed in diabetes, allowing oxidative damage to accumulate [9]
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