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What happens to GLP-1 in type 2 diabetes
332 Bidirectional crosstalk between CAFs and TAMs amplifies immune suppression
We observed an initial blunted response at time points 10 ( BrAC Control = 0.037, BrAC GLP-1RA = 0.021, t(113) = 3.21, p = 0.014), 15 ( BrAC Control = 0.028, BrAC GLP-1RA = 0.013, t(113) = 2.98, p = 0.028) and 20 min (BrAC Control = 0.037, BrAC GLP-1RA = 0.017, t(113) = 3.87, p = 0.001) in the GLP-1RA group as compared to the control group
This indicates that AR abundance and activity is a major determinant of prostate cancer response to SPA in vitro
The TGF-/SMAD pathway is critical in regulating fibroblast activity, promoting extracellular matrix deposition by upregulating the production of collagen, fibronectin, and proteoglycans
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