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Fourteen days after T cell transfer, the greatest numbers of IFN-producing intratumoral CD8 + T cells (Figure 2M) were observed in mice that received A2ARi-treated GPX4-overexpressing CD8 + T cells, but with similar exhausted-like phenotype (expressing PD-1) (Supplemental Figure 4N) and stem-like phenotype (expressing Ly108) (Supplemental Figure 4O)
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Even here, CagriSema delivered 13.7% mean weight reduction at 68 weeks compared to 3.4% with placebo
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