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4.4 Interactions between cartilage and synovium 4.4.1 Interplay between cytokines released by chondrocytes and synovial cells When cartilage is damaged, chondrocytes release proteoglycan fragments, type II collagen fragments, and diverse injury-associated factors that synovial cell surface pattern recognition receptors (PRRs) can detect, prompting synovial hyperplasia and proinflammatory cytokine secretion (1, 139)

The higher potency of Receptor Grade IGF-1 LR3 towards the IGF-1 receptors may make it the preferred molecule for studies involving cell division

Milaneschi Y, Arnold M, Kastenmller G, Dehkordi SM, Krishnan RR, Dunlop BW, et al

Three amino acids make up it: glycine, cysteine, and glutamine