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Because water-soluble vitamins are rapidly excreted, the risk of consuming them in excess is relatively small

Additionally, as noted earlier, there is a risk that there is a rebound in weight

This results in excessive formation of the dipeptide -glutamylcysteine, which is converted by -glutamyl cyclotransferase into 5-oxoproline

These processes, in turn, decrease insulin-stimulated IRS-1/IRS-2 tyrosine phosphorylation, PI3K activation and downstream insulin signaling that then induces IR in muscles and livers