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We need large-scale, long-duration trials with direct muscle function measurements to draw firm conclusions across broader patient populations, including those with sarcopenia, cachexia, or heart disease
-Tocopherol (50 M) and tert-Butyl hydroperoxide (25 M) (Sigma, St Louis, MO) were used as negative and positive controls and added for 2h to the cultures
They work differently, produce different results, and one might work when the other doesn't
The delayed gastric emptying from GLP-1 activation makes the stomach less tolerant of large meals
however, this study adds to the growing evidence of a multi-pronged combination approach addressing obesity as a long-term condition
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