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The glucagon-like peptide-1 receptor agonists (GLP-1 RAs), and now next-generation multi-agonists that include GLP-1 activity, are producing average weight reductions far larger than previously expected from drugs, reshaping clinical practice and how clinicians and patients think about obesity treatment

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E., Burk, R

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Lancet Diabetes Endocrinol 2022;10:393-406.ArticlePubMed 134

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Everything else is shared, a 23-membered macrocycle closed by a lactam bridge between the aspartate side-chain carboxyl at position 5 and the lysine side-chain amine at position 10, norleucine at position 4 in place of the oxidation-prone methionine of the native hormone, and D-phenylalanine at position 7 inside the conserved His-Phe-Arg-Trp message core

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Intestinal Blockage One of the less common but severe complications associated with GLP-1 drugs is intestinal blockage

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