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It's important for individuals with asthma to be aware of the potential risks associated with this treatment and to speak with their healthcare provider about alternative options

Localization of TRPV1 and contractile effect of capsaicin in mouse large intestine: high abundance and sensitivity in rectum and distal colon

It is thought that between 17-20% (Afrin, 2023) of the worlds population has some sort of Mast Cell Activation problem, as it is thought to underlie asthma, dementia, irritable bowel syndrome, Hypermobile-Ehlers Danlos Syndrome, fibromyalgia, skin rashes, chronic fatigue syndrome, long covid as well as many other common conditions

The semaglutide onset timeline article explains the pharmacokinetics in more detail