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The pivotal regulatory enzyme pyruvate kinase M2 (PKM2) functions as a central metabolic switch, mechanistically reflecting the Warburg effect observed in hepatocarcinogenesis (65)
Its full scientific designation is Body Protection Compound-157, and it has been the subject of over 100 peer-reviewed studies, primarily in animal models, with growing human clinical application
Vector and insert fragments were linearized by polymerase chain reaction (PCR) and template DNA was digested with DpnI
Biochem ., 1990 , 190 , 360
This study identified the HNF4A - NCOA4 axis and ferritinophagy as crucial factors in hepatocyte ferroptosis and the pathogenesis of acute liver failure (ALF)
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