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These designs allow for pre-specified modifications, such as dose adjustments, reallocation of participants, or sample size recalibration, based on interim data, without compromising statistical rigor

For rapidly spreading redness, significant swelling, severe pain, or fever at an injection site, seek same-day assessment by contacting NHS 111 or your GP

Kushner, an obesity researcher at Northwestern University Feinberg School of Medicine, who led the study

"In just a few weeks I felt a noticeable difference in the clarity of my skin and I feel great." - Alex N

dose adjustment as per protocol 3 months : Evaluation of weight loss trajectory, HbA1c (if diabetic), and treatment tolerability