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These findings suggest that lower circulating MOTS-c levels are associated with impaired coronary endothelial function, indicating MOTS-c as a potential research subject in the context of ED

doi:10.1186/s13195-024-01666-7

Prolonged GH elevation can reduce insulin sensitivity and affect blood glucose management

It will also be important to determine whether these drugs can be used in combination with other therapies to optimize the treatment of HFpEF in obese patients, while minimizing side effects and drug interactions

And they also exhibit partial and reversible tachyphylaxis, which means their ability to release more growth hormone will improve with consistent and long-term use