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The trial demonstrated that participants switching to orforglipron maintained their weight loss effectively, with an average difference of 0.9 kg for those switching from Wegovy and 5.0 kg for those from Zepbound after 52 weeks

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Tirzepatide works by slowing stomach emptying and activating appetite-suppressing receptors in your brain, which can reduce thirst cues even as your body needs more fluid

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Mounjaro (tirzepatide) is a dual GIP and GLP-1 receptor agonist licensed in the UK for weight management and type 2 diabetes