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In an open-label case series, pyridostigmine was beneficial in relief of symptoms in children with such upper gastrointestinal motility problems as chronic intestinal pseudo-obstruction, delayed small bowel transit accompanying gastroparesis, and chronic constipation associated with failure to thrive
Although the drug makers knew or should have known that the mechanism of action for these drugs may leave some users with painful and debilitating gastrointestinal side effects, a desire for profits was placed before the safety of consumers
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