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Recently, it has been found that miR-205 deregulates lipid metabolism in hepatocellular carcinoma by targeting acyl-CoA synthetase ACSL1, a lipid metabolism enzyme in liver 95
This raises the notion that perhaps within konzo-prone regions of sub-Saharan Africa there may be genetic variants of GPx3, or genes related to associated pathways that circulate which could alter gene expression and subsequently cause a reduction of protein abundances in these populations
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Additionally, the heightened scrutiny of PBM practices may result in renegotiated contract terms, potentially affecting employer cost burdens
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