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If results plateau at 400mcg after four weeks, consider 500mcg for the remainder of the cycle
Higher-exposure protocol design: Advanced daily totals demand tighter monitoring and cleaner execution
(4) Research has demonstrated that NNMT inhibition results in increased intracellular nicotinamide and SAM levels
What this data doesn't tell us: whether NNMT suppression sustained beyond 12 weeks alters NAD+ metabolism in ways that affect mitochondrial function, whether methylation pathway compensation occurs over longer timescales, or whether adipose tissue remodeling continues linearly or plateaus
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