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GLP-1RAs promote glucose uptake in the skeletal muscle by increasing microvascular blood flow and tissue perfusion and inhibit muscle catabolism via the AMP-activated protein kinase pathway [39, 77, 83]

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182,183 Furthermore, inhibited ceramide synthesis or stimulation of ceramide degradation 176 can prevent the effects of ceramide on Akt/PKB activation and improve insulin signaling

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Excessive activation of Notch signaling in macrophages promote kidney inflammation, fibrosis, and necroptosis

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