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Reported research dosing derives from rodent studies rather than established human protocols

Bariatric surgery already produces significant changes in gut hormone secretion, including endogenous GLP-1 elevation, which raises important questions about the incremental benefit of exogenous GLP-1 agonists in this altered physiological state

These mechanisms are interesting on paper, but they come almost entirely from animals and cells

Appetite response is dose-dependent, and many patients do not experience meaningful suppression until the mid-to-high range

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