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In order to measure GSH at real-time, a ratiometric genetically encoded nanosensor was developed using fluorescent proteins and fluorescence resonance energy transfer (FRET) approach
Peng, B., Kong, G., Yang, C
Targeting one carbon metabolism with an antimetabolite disrupts pyrimidine homeostasis and induces nucleotide overflow
The peptide counteracted picrotoxin (non-competitive GABA receptor Cl channel blocker), isoniazid (inhibitor of glutamic acid decarboxylase and GABA synthesis), and bicuculline (GABA-A antagonist), all through dose-dependent protective effects without producing behavioral changes when administered alone
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