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Pros: FDA-approved, proven safety record Cons: Lower average weight loss in studies than retatrutide Tirzepatide Tirzepatide combines GLP-1 and GIP receptor targeting, offering around 21% weight loss and additional metabolic benefits
One genetic study described an enhanced effect on cocaine use in GLP-1R knockout mice achieved via viral-vector delivery of the gene encoding for GLP-1R to the dorso-lateral septum 95
For type 2 diabetes, tirzepatide is indicated as an adjunct to diet and exercise
Saltiel AR, Kahn CR
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