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The gold-standard for diagnosing gout is identification of intracellular monosodium urate crystals with polarising light microscopy in aspirated fluid from the affected joint
Seiler A, Schneider M, Frster H, Roth S, Wirth EK, Culmsee C et al (2008) Glutathione peroxidase 4 senses and translates oxidative stress into 12/15-lipoxygenase dependent-and AIF-mediated cell death
Bacteriostatic Water 10mL for reconstitution
Another is in vivo confocal microscopy of fluorescent dextran (MW ~ 10 kDa) that when injected intravenously penetrated the intercellular junctions up the region of the tight junctions
Sian, J., et al
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