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An enzyme called tyrosinase is needed to create melanin (the pigment that causes the brown spots) and while several other skin lightening agents work to inhibit the synthesis of tyrosinase itself (like vitamin C or licorice), arbutin lets tyrosinase be and rather hinders the melanin-forming activity of the enzyme
It also doesn't suggest B 12 supplements as part of nutrition and diet for MS
If nausea or discomfort arises, consult a healthcare provider for advice
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