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And meal sizes need to decrease to match your slower digestion

The pathophysiology involves sensitization of peripheral nociceptors and altered central nervous system processing of sensory information

2022;5(10):e2236131

Cagrilintide generally has a more favourable safety profile with lower rates of gastrointestinal side effects, though nausea and constipation can still occur

**Who should consider it:** Patients who have plateaued on Semaglutide or Tirzepatide, those seeking the highest available efficacy, early adopters comfortable with a medication still in trials, and always under close medical supervision