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The side effect profile of GLP-1-RA includes delayed gastric emptying which may put surgical patients at an increased aspiration risk, even if proper fasting guidelines have been followed

Given that, though the risk of low blood sugar is not higher in older adults, the risk of complications is greater unless those patients commit to carefully monitoring blood sugar levels

In carcinogenicity studies, rats and mice exposed to tirzepatide developed thyroid C-cell adenomas and carcinomas at plasma exposures comparable to or greater than those achieved with maximum recommended human doses

Until those trials are complete, this study serves as a signal, and the research community is treating it as such