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The TGA, which regulates drugs in Australia, has called for Trulicitys label to be updated to reflect this finding

SYN321, a hyaluronic acid sulfatesodium diclofenac conjugate for sustained intraarticular NSAID delivery and lubrication, was evaluated on an OA-on-chip platform (uBeat MultiCompress) capable of up to 30% compressive strain

Although tamoxifen and its metabolites (i.e., 4-hydroxytamoxifen) can cross the blood-brain barrier, these compounds have reduced bioavailability in the brain compared to other tissues 34

Injections may incur higher costs due to clinic visits and professional administration

Induction of nitric oxide synthesis lowers intracellular glutathione in microglia of primary glial cultures