Vitamin B12 shots can help restore healthy vitamin levels in individuals who may have a deficiency or difficulty absorbing B12 through diet alone
development as an obesity drug was not continued
However, some people can still become low in B12 because of diet, absorption problems, certain medical conditions, medicines, surgery or long-term health factors
Conditions include alcoholic liver disease, viral hepatitis, cirrhosis, and primary or metastatic liver cancer Renal dysfunction : Impaired kidney function reduces B12 elimination, causing accumulation even with normal intake Haematological conditions : Myeloproliferative neoplasms, chronic myeloid leukaemia, polycythaemia vera, and hypereosinophilic syndrome increase transcobalamin production, elevating total serum B12 Laboratory interference : Macro-B12 (immunoglobulin-bound B12) and assay interference can cause spuriously elevated results without true excess In clinical practice, unexplained hypercobalaminaemia should prompt investigation for underlying disease, particularly in patients without obvious supplementation history
However, the possibility of underdosing, contamination, or formulation errors exists in compounded products