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Expert Review Endocrinology Metabolism , 18
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In a study with 740 patients, tesofensine at different doses resulted in weight loss of -0.9%, -1.32%, and -2.32% compared to a slight increase in the placebo group
Oral semaglutide offers a familiar molecule in pill form, with meaningful efficacy and cardiovascular data from the SELECT trial
509 AS-252424 is a specific and targeted ACSL4 inhibitor that binds directly to the glutamine 464 of ACSL4 to inhibit its enzymatic activity, thereby inhibiting lipid peroxidation and ferroptosis, effectively alleviating ferroptosis-mediated organ damage in mouse models, including I/R-induced kidney injury and acute liver injury
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