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As an example, we have previously shown that adenovirus-mediated induction in human adult OLs of low levels of p53, a transcription factor that regulates apoptosis and can be detected in OLs in actively demyelinating MS lesions, renders these cells susceptible to subsequent FasL- and TRAIL-medicated killing 45
Several pathways are required to maintain redox homeostasis, in particular the glutathione-glutaredoxin and thioredoxin-thioredoxin reductase systems 1
SH2022062
However, without the right approach, this weight loss can come at the expense of muscle mass
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